{"id":1025,"date":"2024-04-08T12:52:57","date_gmt":"2024-04-08T09:52:57","guid":{"rendered":"https:\/\/colyakvakfi.org\/?p=1025"},"modified":"2024-04-08T12:53:47","modified_gmt":"2024-04-08T09:53:47","slug":"colyak-nedir","status":"publish","type":"post","link":"https:\/\/otoson.com.tr\/demo\/colyak-nedir\/","title":{"rendered":"\u00c7\u00f6lyak Nedir?"},"content":{"rendered":"\n

\u00c7\u00f6lyak hastal\u0131\u011f\u0131 di\u011fer bir ad\u0131yla gluten enteropatisi, bu\u011fday, arpa ve \u00e7avdar gibi \u00fcr\u00fcnlerde bulunan gl\u00fcten adl\u0131 proteinin v\u00fccuda al\u0131nmas\u0131 ile ortaya \u00e7\u0131kan otoimm\u00fcn ve genetik yatk\u0131nl\u0131\u011f\u0131 olan bir hastal\u0131kt\u0131r.<\/p>\n\n\n\n

Ba\u011f\u0131\u015f\u0131kl\u0131k sistemimiz bakteri, vir\u00fcs gibi zararl\u0131 maddelere kar\u015f\u0131 antikor \u00fcreterek v\u00fccudumuzu korumakla g\u00f6revlidir. Ancak bazen zarars\u0131z olabilecek maddelere kar\u015f\u0131 da antikor olu\u015fturabilir. \u00c7\u00f6lyak hastal\u0131\u011f\u0131nda v\u00fccuda gluten al\u0131nd\u0131ktan sonra ba\u011f\u0131\u015f\u0131kl\u0131k sistemimiz antikor \u00fcretmeye ba\u015flar. \u00dcretilen bu antikor ince ba\u011f\u0131rsaklarda besinlerin emiliminden sorumlu olan villus ad\u0131 verilen parmaks\u0131 \u00e7\u0131k\u0131nt\u0131lara zarar verir. Zamanla villuslar\u0131n boylar\u0131 k\u0131sal\u0131r ve yap\u0131s\u0131 d\u00fcz bir hale gelir. Bu durumda ki\u015fi t\u00fcketti\u011fi besin \u00f6gelerinin emilimi sa\u011flayamaz. \u00d6zellikle demir, folat gibi minerallerin emiliminde azalmalar meydana gelir.<\/p>\n\n\n

\n
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\u00c7\u00f6lyak Hastal\u0131\u011f\u0131nda Villus<\/figcaption><\/figure><\/div>\n\n\n

Hastal\u0131k her ya\u015fta ortaya \u00e7\u0131kabilir. \u0130leri ya\u015flarda ortaya \u00e7\u0131kan \u00e7\u00f6lyak hastal\u0131\u011f\u0131nda semptomlar daha fazla g\u00f6r\u00fclebilir.  \u00c7\u00f6lyak hastal\u0131\u011f\u0131n\u0131n toplumumuzda g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 % 1\u2019dir. Yani her 100 ki\u015fiden 1\u2019i \u00e7\u00f6lyak hastas\u0131d\u0131r. Ayn\u0131 zamanda genetik yatk\u0131nl\u0131\u011f\u0131 olan bir hastal\u0131k oldu\u011fundan dolay\u0131 ailede \u00e7\u00f6lyak hikayesi varsa ki\u015finin hastal\u0131\u011fa sahip olma olas\u0131l\u0131\u011f\u0131 artar.<\/p>\n\n\n\n

\u00c7\u00f6lyak hastal\u0131\u011f\u0131 di\u011fer otoimm\u00fcn hastal\u0131klar da ba\u011flant\u0131l\u0131 olabilir. \u00c7\u00f6lyak hastal\u0131\u011f\u0131n\u0131n Tip 1 diyabetli ki\u015filerde g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 %3-12, otoimm\u00fcn tiroit hastal\u0131\u011f\u0131 olan bireylerde g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 %3, otoimm\u00fcn karaci\u011fer hastal\u0131\u011f\u0131 olan bireylerde g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 %13,5 olarak saptanm\u0131\u015ft\u0131r. Ayr\u0131ca Down, Turner ve Williams sendromu gibi kromozomal bozukluklarda da \u00e7\u00f6lyak hastal\u0131\u011f\u0131 s\u0131kl\u0131\u011f\u0131 artmaktad\u0131r. Yap\u0131lan \u00e7al\u0131\u015fmalarda kromozomal bozuklu\u011fu ki\u015filerde \u00e7\u00f6lyak hastal\u0131\u011f\u0131 g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 %5,5-%9,5 aras\u0131 oldu\u011fu bildirilmi\u015ftir. Ki\u015fide otoimm\u00fcn bir hastal\u0131k ve\/veya kromozomal bozukluklar mevcut ise ki\u015fi \u00e7\u00f6lyak hastal\u0131\u011f\u0131 a\u00e7\u0131s\u0131ndan da taranmal\u0131d\u0131r.<\/p>\n\n\n\n

Tip 1 DM<\/td>%3-12<\/td><\/tr>
Otoimmun tiroid hastal\u0131klar\u0131<\/td>%3<\/td><\/tr>
Otoimmun karaci\u011fer hastal\u0131klar\u0131<\/td>%13,5<\/td><\/tr><\/tbody><\/table><\/div>
Otoimmun Hastal\u0131klar<\/figcaption><\/figure>\n\n\n\n
Down sendromu<\/td>%5,5<\/td><\/tr>
Turner sendromu<\/td>%6,5<\/td><\/tr>
Williams sendromu<\/td>%9,5<\/td><\/tr><\/tbody><\/table><\/div>
Kromozomal Bozukluklar<\/figcaption><\/figure>\n\n\n\n

\u00c7\u00f6lyak hastal\u0131\u011f\u0131n\u0131n bilinen tek tedavisi \u00f6m\u00fcr boyu s\u00fcrecek olan kat\u0131 glutensiz diyettir. Ki\u015fi diyetine uyum sa\u011flad\u0131\u011f\u0131 taktirde semptomlar ortadan kalkacakt\u0131r.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\n\n\n\n

\u00c7\u00f6lyak Belirtileri Nelerdir?<\/h2>\n\n\n\n
\n
\n

2 Ya\u015f Alt\u0131 \u00c7ocuklarda<\/h4>\n\n\n\n
    \n
  • Geli\u015fme gerili\u011fi<\/li>\n\n\n\n
  • Kusma<\/li>\n\n\n\n
  • Kronik ishal<\/li>\n\n\n\n
  • Kar\u0131nda \u015fi\u015flik<\/li>\n\n\n\n
  • \u0130\u015ftahs\u0131zl\u0131k<\/li>\n<\/ul>\n<\/div>\n\n\n\n
    \n

    2 Ya\u015f \u00dcst\u00fc \u00c7ocuklarda<\/h4>\n\n\n\n
      \n
    • Akranlar\u0131ndan daha k\u0131sa ve zay\u0131f olma<\/li>\n\n\n\n
    • Geli\u015fimin yava\u015flamas\u0131<\/li>\n\n\n\n
    • Ergenlikte gecikme<\/li>\n\n\n\n
    • Kilo kayb\u0131<\/li>\n\n\n\n
    • Birka\u00e7 haftad\u0131r ge\u00e7meyen ishal<\/li>\n\n\n\n
    • Kronik kab\u0131zl\u0131k ve kusma<\/li>\n\n\n\n
    • Sinirlilik<\/li>\n\n\n\n
    • Dikkat eksikli\u011fi<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n

      Yeti\u015fkinlerde<\/h4>\n\n\n\n
      \n
      \n
        \n
      • Kar\u0131n \u015fi\u015fli\u011fi<\/li>\n\n\n\n
      • \u0130shal<\/li>\n\n\n\n
      • Kab\u0131zl\u0131k<\/li>\n\n\n\n
      • Kar\u0131n a\u011fr\u0131s\u0131 ve kramp<\/li>\n\n\n\n
      • Kilo kayb\u0131<\/li>\n\n\n\n
      • Kemik veya eklem a\u011fr\u0131s\u0131<\/li>\n\n\n\n
      • Ba\u015f a\u011fr\u0131s\u0131<\/li>\n\n\n\n
      • K\u0131s\u0131rl\u0131k<\/li>\n\n\n\n
      • A\u00e7\u0131k renkli ya da k\u00f6t\u00fc kokulu d\u0131\u015fk\u0131<\/li>\n\n\n\n
      • Tuvalet ihtiyac\u0131n\u0131n artmas\u0131<\/li>\n<\/ul>\n<\/div>\n\n\n\n
        \n
          \n
        • Kans\u0131zl\u0131k\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li>\n\n\n\n
        • Kusma<\/li>\n\n\n\n
        • Deri d\u00f6k\u00fcnt\u00fcleri<\/li>\n\n\n\n
        • \u0130\u015ftahs\u0131zl\u0131k ve gaz \u015fikayetleri<\/li>\n\n\n\n
        • Yorgunluk ve halsizlik<\/li>\n\n\n\n
        • Demir eksikli\u011fi<\/li>\n\n\n\n
        • Nedeni bilinmeyen karaci\u011fer hastal\u0131klar\u0131<\/li>\n\n\n\n
        • Duygudurum de\u011fi\u015fiklikleri, sinirlilik ve depresyon<\/li>\n\n\n\n
        • Di\u015f minesi sorunlar\u0131\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n

          \u00c7\u00d6LYAK \u00c7E\u015e\u0130TLER\u0130 NELERD\u0130R?                <\/h2>\n\n\n\n

          Tipik (Klasik) \u00c7\u00f6lyak Hastal\u0131\u011f\u0131<\/h3>\n\n\n\n

          Daha \u00e7ok s\u00fct \u00e7ocuklar\u0131 ve k\u00fc\u00e7\u00fck \u00e7ocuklarda, ya\u015fam\u0131n 6-24. aylar\u0131nda, diyete glutenin girmesiyle ortaya \u00e7\u0131kan, tipik olarak b\u00fcy\u00fcme-geli\u015fme gerili\u011fi, kronik ishal, kar\u0131n \u015fi\u015fli\u011fi, kar\u0131n a\u011fr\u0131s\u0131, kusma, i\u015ftahs\u0131zl\u0131k, kas g\u00fc\u00e7s\u00fczl\u00fc\u011f\u00fc ve hipotoni gibi gastrointestinal sistem (G\u0130S) bulgular\u0131 ile karakterizedir. Diyetle al\u0131nan gluten miktar\u0131 ve bireyin ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131na g\u00f6re haftalar ya da aylar sonra klinik bulgular ortaya \u00e7\u0131kabilir. D\u0131\u015fk\u0131 tipik olarak c\u0131v\u0131k, ya\u011fl\u0131 g\u00f6r\u00fcn\u00fcmde ve pis kokuludur. Emosyonel olarak bu \u00e7ocuklar \u00e7ok huzursuz, huysuz ve mutsuz olabilirler.<\/p>\n\n\n\n

          Atipik \u00c7\u00f6lyak Hastal\u0131\u011f\u0131<\/h3>\n\n\n\n

          Genellikle b\u00fcy\u00fck \u00e7ocuk ve eri\u015fkinlerde g\u00f6r\u00fcl\u00fcr. Malabsorpsiyon bulgular\u0131 yoktur. Boy k\u0131sal\u0131\u011f\u0131, puberte gecikmesi, dermatitis herpetiformis, di\u015f mine tabaka bozuklu\u011fu, tedaviye diren\u00e7li demir eksikli\u011fi anemisi, osteoporoz, artrit, aft\u00f6z stomatit, a\u00e7\u0131klanamayan transaminaz y\u00fcksekli\u011fi, n\u00f6rolojik bozukluklar gibi belirti ve bulgular\u0131n yan\u0131 s\u0131ra irritabl ba\u011f\u0131rsak hastal\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcren dispeptik yak\u0131nmalar ve kab\u0131zl\u0131k gibi atipik gastrointestinal belirtiler ile karakterizedir.<\/p>\n\n\n\n

          Sessiz \u00c7\u00f6lyak Hastal\u0131\u011f\u0131<\/h3>\n\n\n\n

          Sessiz \u00e7\u00f6lyak hastal\u0131\u011f\u0131 sa\u011flam g\u00f6r\u00fcn\u00fcml\u00fc ve herhangi bir yak\u0131nmas\u0131 olmayan bir \u00e7ocukta veya eri\u015fkinde \u00e7\u00f6lyak hastal\u0131\u011f\u0131n\u0131 destekleyen yeterli klinik belirti ve bulgu olmadan, \u00e7\u00f6lyak hastal\u0131\u011f\u0131na \u00f6zg\u00fcl antikorlar\u0131n, doku grubunun ve ince ba\u011f\u0131rsak biyopsi bulgular\u0131n\u0131n saptanmas\u0131d\u0131r. Son y\u0131llarda sessiz \u00e7\u00f6lyak hastalar\u0131n\u0131n \u00e7o\u011funda hafif, g\u00f6zden ka\u00e7abilen hastal\u0131k bulgular\u0131n\u0131n oldu\u011fu ve glutensiz diyet sonras\u0131 fiziksel ve psikolojik a\u00e7\u0131dan kendilerini daha iyi hissettikleri g\u00f6sterilmi\u015ftir.<\/p>\n\n\n\n

          Potansiyel \u00c7\u00f6lyak Hastal\u0131\u011f\u0131<\/h3>\n\n\n\n

          Kan tahlilinde antikor pozitifli\u011fi oldu\u011fu halde ince ba\u011f\u0131rsak biyopsilerde doku de\u011fi\u015fikliklerin g\u00f6r\u00fclmemesi olarak tan\u0131mlan\u0131r. Bu hastalar HLA DQ2 veya HLA DQ8 gibi \u00e7\u00f6lyak hastal\u0131\u011f\u0131 ile uyumlu doku gruplar\u0131na sahiptirler ve ileri y\u0131llarda \u00e7\u00f6lyak hastal\u0131\u011f\u0131na sahip olma riski ta\u015f\u0131rlar. Bu nedenle bu hastalar\u0131n izlenmesi gerekmektedir.<\/p>\n\n\n\n

          Latent \u00c7\u00f6lyak Hastal\u0131\u011f\u0131<\/h3>\n\n\n\n

          \u00c7\u00f6lyak hastal\u0131\u011f\u0131 ile uyumlu gen grubuna sahip, ancak \u00e7\u00f6lyak hastal\u0131\u011f\u0131 olmayan, hayatlar\u0131n\u0131n bir d\u00f6neminde gluten duyarl\u0131 enteropatisi geli\u015fen ki\u015filerdir. Bu hastalarda \u00e7\u00f6lyak hastal\u0131\u011f\u0131 belirtileri olabilir ya da olmayabilir. Benzer \u015fekilde \u00e7\u00f6lyak hastal\u0131\u011f\u0131 antikorlar\u0131 pozitif ya da negatif olabilir.<\/p>\n\n\n\n

          \u00c7\u00d6LYAK TANI KR\u0130TERLER\u0130<\/h2>\n\n\n\n

          \u00c7\u00f6lyak hastal\u0131\u011f\u0131ndan \u015f\u00fcphelenilen ki\u015filerde aile \u00f6yk\u00fcs\u00fc ve t\u00fcm semptomlar de\u011ferlendirilmelidir. Serolojik tarama testlerinde, antigliadin antikorlar\u0131, endomisyum antikorlar\u0131, transglutaminaz antikorlar\u0131 (Anti-doku transglutaminaz antikorlar\u0131 IgG\/IgA, Anti-endomizyal antikorlar IgG\/IgA, Anti-deamide gliadin antikorlar\u0131) kullan\u0131l\u0131r.<\/p>\n\n\n\n

          Serolojik testler, \u00e7\u00f6lyakl\u0131 hastalar\u0131n durumlar\u0131n\u0131n izlenmesinde de kullan\u0131lan olduk\u00e7a spresifik ve duyarl\u0131 testlerdir. Te\u015fhis i\u00e7in alt\u0131n standart ise ince ba\u011f\u0131rsak biyopsisidir. Ancak g\u00fcncel k\u0131lavuzlarda \u00e7\u00f6lyak hastal\u0131\u011f\u0131 tan\u0131s\u0131 olan baz\u0131 durumlarda, serolojik sonu\u00e7larda e\u011fer anlaml\u0131 oranda pozitiflik varsa ek olarak genetik yatk\u0131nl\u0131k incelemesi olan HLA tiplerinden DQ2, DQ8\u2019den birisi mevcutsa bu \u015fekilde de tan\u0131 konulabilmektedir.Serolojik testler ayn\u0131 zamanda diyete uyumun izlenebilmesi a\u00e7\u0131s\u0131ndan kontrollerde de kullan\u0131lmaktad\u0131r.<\/p>\n\n\n\n

          Diyetine tamamen uyum sa\u011flayan ki\u015filerin serolojik testleri negatife d\u00f6necektir. Unutulmamas\u0131 gereken nokta ise \u00e7\u00f6lyak art\u0131k geride kald\u0131 istedi\u011fimi yiyebilirim gibi bir durum asla s\u00f6z konusu de\u011fildir, \u00e7\u00f6lyak \u00f6m\u00fcr boyu glutensiz beslenme gerektiren otoimm\u00fcn bir hastal\u0131kt\u0131r. \u00c7\u00f6lyak hastal\u0131\u011f\u0131n\u0131n tek tedavi y\u00f6ntemi \u00f6m\u00fcr boyu glutensiz diyettir. Biorezonans gibi y\u00f6ntemlerin bilimsel a\u00e7\u0131dan bir ge\u00e7erlili\u011fi yoktur.<\/p>\n","protected":false},"excerpt":{"rendered":"

          \u00c7\u00f6lyak hastal\u0131\u011f\u0131 di\u011fer bir ad\u0131yla gluten enteropatisi, bu\u011fday, arpa ve \u00e7avdar gibi \u00fcr\u00fcnlerde bulunan gl\u00fcten adl\u0131 proteinin v\u00fccuda al\u0131nmas\u0131 ile ortaya \u00e7\u0131kan otoimm\u00fcn ve genetik yatk\u0131nl\u0131\u011f\u0131 olan bir hastal\u0131kt\u0131r. Ba\u011f\u0131\u015f\u0131kl\u0131k…<\/p>\n","protected":false},"author":1,"featured_media":1026,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"give_campaign_id":0,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[17],"tags":[19],"class_list":["post-1025","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colyak","tag-colyak"],"yoast_head":"\n\u00c7\u00f6lyak Nedir? - \u00c7\u00f6lyak Vakf\u0131<\/title>\n<meta name=\"description\" content=\"\u00c7\u00f6lyak hastal\u0131\u011f\u0131 di\u011fer bir ad\u0131yla gluten enteropatisi, gl\u00fcten adl\u0131 proteinin v\u00fccuda al\u0131nmas\u0131 ile ortaya \u00e7\u0131kan otoimmun bir hastal\u0131kt\u0131r.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/otoson.com.tr\/demo\/colyak-nedir\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c7\u00f6lyak Nedir? 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